ea0081p157 | Pituitary and Neuroendocrinology | ECE2022
Monnerat Sophie
, Atila Cihan
, Bingisser Roland
, Siegemund Martin
, Lampart Maurin
, Ruegg Marco
, Zellweger Nuria
, Osswald Stefan
, Rentsch Katharina
, Christ-Crain Mirjam
, Twerenbold Raphael
Background: Hyponatremia is highly prevalent in patients with COVID-19. One of the most common causes of hyponatremia in these patients is the syndrome of inadequate antidiuresis (SIAD). Interleukin 6 (IL-6) is a key mediator of inflammation in COVID-19. We hypothesized that hyponatremia in COVID-19 is due to IL-6 mediated non-osmotic arginine vasopressin (AVP) secretion, and that the inverse association between IL-6 and plasma sodium concentration is stronger in COVID-19 comp...